Frontiers Satellite cells in human skeletal muscle plasticity IGF 1 Regulates Cancer Cell Immune Evasion in Prostate Cancer OncoDaily Mechanisms of IGF 1 Mediated Regulation of Skeletal Muscle Hypertrophy and Atrophy Researchers can't fully explain why IGF LR3 outperforms its natural counterpart in preclinical models. Engineered in the 1990s with an arginine substitution and N terminal extension, this synthetic IGF 1 analog shows reduced IGFBP binding Activation of satellite cells. Download Scientific Diagram