The Protective Effects of Garlic Extract Against Acetaminophen Induced Oxidative Stress and Glutathione Depletion Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. What will happen to the liver of a patient with fatty liver disease (steatosis) given 4 grams of acetaminophen (paracetamol) per day for 4 weeks? PDF) Erratum to: The effects of acute acetaminophen toxicity on hepatic mRNA expression of SOD, CAT, GSH Px, and levels of peroxynitrite, nitric oxide, reduced glutathione, and malondialdehyde in rabbit Does Acetaminophen Deplete Glutathione? Understanding the Connection Cymbiotika CYMBIOTIKA