Removal of acetaminophen protein adducts by autophagy protects against acetaminophen induced liver injury in mice Journal of Hepatology Too much paracetamol = dangerous because of how your liver processes it. *Normal dose:* About 90 95% gets broken down safely by glucuronidation + sulfation non toxic stuff you pee out. *The problem Recurrent Pyroglutamic Acidosis Related to Therapeutic Acetaminophen The American Journal of the Medical Sciences The biochemistry of acetaminophen hepatotoxicity and rescue: a mathematical model Theoretical Biology and Medical Modelling Springer Nature Link Up regulation of nuclear related factor 2 (NRF2) and antioxidant responsive elements by metformin protects hepatocytes against the acetaminophen toxic Toxicology Research (RSC Publishing) DOI:10.1039 C4TX00032C